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Study reveals sleep loss hijacks brain’s activity during learning

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Philadelphia [US], November 11 (ANI): Partially sleep-deprived individuals might be especially vulnerable to fear-related conditions such as posttraumatic stress disorder or anxiety, according to a new research.
The study appears in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, published by Elsevier.
“This study provides us with new insights into how sleep deprivation affects brain function to disrupt fear extinction,” said Cameron Carter, MD, Editor of Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.
The researchers, led by Anne Germain, PhD, at the University of Pittsburgh and Edward Pace-Schott, PhD, at Harvard Medical School and Massachusetts General Hospital, studied 150 healthy adults in the sleep laboratory. One-third of subjects got normal sleep, one third were sleep restricted and they slept only the first half the night, and one third were sleep-deprived, so they did not sleep at all. In the morning, all the subjects underwent fear conditioning.
“Our team used a three-phase experimental model for the acquisition and overcoming of fearful memories while their brains were scanned using functional magnetic resonance imaging,” said Dr Pace-Schott.
Brain imaging recorded during the tasks showed activation in brain areas associated with emotional regulation, such as the prefrontal cortex, in people who received normal sleep. But the brain activity looked very different in people with restricted sleep, said Dr Pace-Schott. “We found that among the three groups, those who had only gotten half a night’s sleep showed the most activity in brain regions associated with fear and the least activity in areas associated with control of emotion.”
Surprisingly, people who got no sleep lacked brain activation in fear-related areas during fear conditioning and extinction. During the extinction recall 12 hours later, their brain activity looked more similar to those with normal sleep, suggesting that a limited night of sleep may be worse than none at all.
The researchers hypothesize that sleeping only half the night results in a loss of rapid eye movement (REM) sleep, which has been shown to be important for memory consolidation and usually happens toward the end of a normal sleep period.
Dr Carter said the study used “noninvasive brain imaging to give us a novel window into how sleep deprivation disrupts the normal fear extinction mechanisms and potentially increases vulnerability to posttraumatic stress symptoms.”
“Medical workers and soldiers often have curtailed or interrupted sleep rather than missing an entire night’s sleep,” Dr Pace-Schott said. (ANI)

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