hi INDiA Copyright 2020
Indian American MU Researcher IDs Four Potential Treatments for COVID-19
NEW YORK, NY- – A team from the University of Missouri let by an Indian American scientist has found that four antiviral drugs, including remdesivir, a drug originally developed to treat Ebola, are effective in inhibiting the replication of the coronavirus causing COVID-19.
Kamlendra Singh, an associate professor in the College of Veterinary Medicine, and his team used computer-aided drug design to examine the effectiveness of remdesivir, 5-fluorouracil, ribavirin and favipiravir in treating COVID-19.
According to the study, published in the journal Pathogens, Singh found that all four drugs were effective in inhibiting, or blocking, the coronavirus’ RNA proteins from making genomic copies of the virus.
“As researchers, we have an obligation to search for possible treatments given that so many people are dying from this virus,” Singh said.
These antiviral drugs, if they turn out to be effective, all have some limitations.
“But in the midst of a global pandemic, they are worth taking a deeper look at because based on our research, we have reason to believe that all of these drugs could potentially be effective in treating COVID-19,” he added.
The coronavirus (SARS-CoV-2) that causes COVID-19, like all viruses, can mutate and develop resistance to antiviral drugs.
Therefore, further testing in a laboratory setting and in patients is needed to better evaluate how the proposed treatments interact with the virus’ RNA polymerase.
Singh’s research is an example of translational medicine, a key component of the University of Missouri System’s NextGen Precision Health Initiative.
Meanwhile, the U.S. is planning to begin treating some of the most seriously ill COVID-19 patients with the antiviral medication Remdesivir, the maker of the drug has announced, as tensions continued across the country over the economic reopening of states.
Last week, the Food and Drug Administration granted Emergency Use Authorization for the experimental anti-viral drug remdesivir to treat COVID-19.
As of May 5, confirmed cases in the country had reached 1,180,634 with 68,934 deaths, according to the tally maintained by Johns Hopkins University.